Archive for the ‘zanamivir’ Tag

Influenza treatment: recommended dosages   1 comment

Treatment course: 5 days

M2 Inhibitors (effective against influenza A only)
Amantadine (Symmetrel)

  • <10y/o: 5mg/kg/d up to 150mg in 2 div doses (include those older than 10 but <40kg)
  • 10y/o and above: 100mg bd
  • 65y/o and above: 100mg/d or less
  • *consult package insert if CrCl <50ml/min

Rimantadine (Flumadine)

  • use in children <13y/o: off-label
  • 13y/o and above: 100mg bd
  • 65y/o and above: 100mg/d
  • *hepatic dysfunction, CrCl <10ml/min: reduce to 100mg/d

 

Neuraminidase Inhibitors (effective against influenza A & B)
Oseltamivir (Tamiflu)

  • 0 to <12 months: 3mg/kg bd
    12 months & above:

  • 15kg or less: 30mg bd
  • 15-23kg: 45mg bd
  • 23-40kg: 60mg bd
  • >40kg and adults: 75mg bd
  • *reduce dose if CrCl <30ml/min

Zanamivir (Relenza)

  • 7y/o and above: 10mg (2 inhalations) bd

 
Ref:

  1. CDC: Table: Recommended Daily Dosage of Seasonal Influenza Antiviral Medications for Treatment and Chemoprophylaxis for the 2008-09 Season—United States. Available at:
    http://www.cdc.gov/flu/professionals/antivirals/dosagetable.htm#table

  2. CDC: Table: Antiviral medication dosing recommendations for treatment or chemoprophylaxis of 2009 H1N1 infection. Available at:
    http://www.cdc.gov/h1n1flu/recommendations.htm#table1