Archive for the ‘viral hepatitis’ Tag

Avaxim (Sanofi Pasteur)   Leave a comment

AVaxim™ 160 U (Sanofi Pasteur)
(Hepatitis A vaccine)

Vaccine Type: inactivated adsorbed vaccine
Composition: inactivated Hepatitis A virus, GBM strain, 160 units, cultured on MRC-5 human diploid cells, adsorbed on aluminium hydroxide (= 0.3mg of Al).

Dosage:

  • indicated for active immunisation from 16 years of age
  • 0.5ml per dose: im/sc one primary dose
  • booster for long-term protection: preferably 6-12 months, but may be administered up to 36 months after first dose
  • Avaxim may be used as booster dose if primary dose was given with another inactivated Hep A vaccine

Contraindicated in:

  • hypersensitivity to neomycin
  • not to be injected in the buttocks or intradermally
  • delay vaccination if acute severe febrile illness
  • response may be reduced in immunosuppressed
  • no studies done in subjects with liver disease

Pregnancy: avoid except in major contamination risk.
Lactation: consider benefit of breastfeeding for child, versus Avaxim for woman.

Adverse reactions:
usually mild, confined to first few days with spontaneous recovery

  • nausea, vomiting, diarrhoea, abdominal pain
  • headache, myalgia, arthralgia, asthenia
  • mild injection site pain, mild fever

Drug interactions:

  • immunoglobulins may be administered together at a different injection site
  • may be given with other inactivated vaccines at different site, including Typhim Vi and yellow fever vaccine

 

Ref:

  1. promotional material, Sanofi Pasteur
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Posted December 13, 2011 by absinthemisia in viral hepatitis, Virology

Tagged with , , ,

Hepatitis vaccine: Twinrix™   Leave a comment

Twinrix™ (GSK)
(from package insert, April 2004)

Vaccine type: combined inactivated Hepatitis A and surface antigen Hepatitis B

Composition (per 1.0ml dose):
720 ELISA units Hep A virus and 20mcg recombinant HBsAg

Dosage:

  • 16yo and above (3 doses): 1.0ml at 0, 1 month, 6 months (after 1st dose)
  • alternatively, if travel is anticipated urgently: 0, 7 days, 21 days; booster at 12 months
  • 1-15yo (2 doses): 1.0ml at 0 then 6-12 months
  • booster: Twinrix™ can be used if booster of both Hep A & B required. Alternatively, either monovalent vaccine may be used separately

  • intramuscular injection into deltoid or anterolateral thigh (infants); avoid gluteal

  • subcutaneous route may be used in bleeding disorders but suboptimal immune response may result

Contraindicated in:

  • anaphylaxis to neomycin
  • postpone in subjects with acute severe febrile illness

Use in pregnancy/lactation:

  • adequate data not available, but not expected to harm the foetus
  • used during pregnancy only when there is a clear risk of Hep A and B
  • use with caution in breastfeeding women

Some side effects:

  • common: fatigue, headache, malaise, nausea
  • uncommon: fever, vomiting
  • SE involving other organ systems are very rare