Archive for the ‘PPI’ Tag

How may GERD be treated in an empirical trial of treatment without OGD?   Leave a comment

Uninvestigated typical reflux symptoms (heartburn, acid regurgitation)

  • alarm features* present: refer for OGD
  • alarm features* absent: PPI therapy 4w (review 2-4w)
    • symptoms persist: stop PPI for 1w and refer for OGD
    • symptoms respond: trial of stopping PPI
      • relapse: restart PPI, on-demand therapy
      • frequent relapses, or alarm features*: refer for OGD

 

*What are the alarm features that would prompt an OGD?

  • weight loss
  • anaemia
  • anorexia
  • progressive dysphagia
  • odynophgia
  • vomiting
  • family history of upper GI cancer
  • GERD symptoms in older patients (>40 years) in areas with a high prevalence of gastric cancer

 

Ref:

  1. From promotional material, AstraZeneca: Fock KM et al. Jour Gastroenterol Hepatol 2008;(23):8-22.
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Posted October 28, 2011 by absinthemisia in Gastroenterology

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Nexium Dosage Guide (from AstraZeneca)   Leave a comment

** refers to oral dosage only

GERD

  • endoscopy positive: 40mg om 4-8w, then 20mg om for maintenance
  • endoscopy negative: 20mg om until symptom controlled, then 20mg on demand

Peptic ulcers

  • H. pylori associated: 20mg bd (as part of triple therapy) 7d
  • NSAIDs associated: 20mg om 4-8w, then 20mg om for maintenance

Zollinger-Ellison Syndrome

  • 40mg bd initially, majority may be kept on 80-160mg/d
  • doses above 80mg to be divided bd

Posted October 28, 2011 by absinthemisia in Gastroenterology

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