Priorix-Tetra™ (GSK, Belgium)
(Measles, mumps, rubella and varicella vaccine)
Vaccine Type: live attentuated vaccine for all 4 viruses
Composition:
- live attenuated measles virus (Schwarz strain)*
- live attenuated mumps virus (RIT 4385 strain)*
- live attenuated rubella virus (Wistar RA 27/3 strain) produced in human diploid (MRC-5) cells
- live attenuated varicella virus (OKA strain)*
* produced in chick embryo cells
Dosage:
- 0.5ml per dose: subcutaneous inj preferably outer aspect of upper arm
- see Singapore’s childhood immunisation schedule
- preferably at least 6-week interval between doses: must not be < 4 weeks
- indicated for active immunisation from 12 months to 12 years
Contraindicated in:
- hypersensitivity to neomycin
- impaired immune systems eg. primary/secondary immunodeficiency
- pregnant females
- anaphylactoid/acute reaction to egg: at higher risk of similar reaction but not common; vaccinate with extreme caution
- history of febrile convulsions: follow-up closely 4-12 days for vaccine-related fever
- acute febrile illness: postpone
- transmission of varicella vaccine virus rarely possible; MMR transmission never documented
- vaccinate asymptomatic HIV patients with caution, at physician’s discretion
Pregnancy: contraindicated
and avoid getting pregnant for three months after vaccination. There is inadequate data on use during lactation.
Drug interactions:
- tuberculin testing: to be carried out before or simultaneously with vaccination (as MMR may cause temporary depression in tuberculin skin sensitivity), otherwise withhold for up to 6 weeks to avoid false negative results
- gammaglobulins, blood transfusion: delay for at least 3 months due to passively acquired antibodies causing vaccine failure
- salicylates: avoid for 6 weeks after vaccination as Reye’s syndrome may occur when salicylates are used following natural varicella infection
Ref:
- Package insert, International Data Sheet version 1 SI (14/02/2007)