Archive for the ‘flu vaccine’ Tag

Influenza vaccine: Vaxigrip NH 2011/2012   Leave a comment

Vaxigrip NH 2011/2012 (sanofi-aventis)
(from promotional material)

Vaccine type: split virion, inactivated influenza vaccine
Composition:
<complies with WHO recommendation)

  • A/California/7/2009(H1N1)
  • A/Perth/16/2009(H3N2)
  • B/Brisbane/60/2008

Available in:

  • Vaxigrip Pediatric 0.25ml for 6-35 months of age
  • Vaxigrip 0.5ml for children & adults 36 months and older

Posted September 12, 2011 by absinthemisia in influenza, vaccination

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Influenza vaccine: influvac 2011/2012   Leave a comment

Influvac® 2011/2012 (Abbott)
(from promotional material)

Vaccine type: viral subunit vaccine (haemagglutinin & neuraminidase)
Composition:

  • A/California/7/2009(H1N1)-like virus
  • A/Perth/16/2009(H3N2)-like virus
  • B/Brisbane/60/2008-like virus

Posted August 12, 2011 by absinthemisia in influenza, vaccination

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Influenza vaccine: influvac 2010/2011   1 comment

Influvac® 2010/2011 (Solvay, Netherlands)
(from package insert, April 2010)

Vaccine type: viral surface antigen (inactivated) (haemagglutinin & neuraminidase)
Composition: complies with WHO recommendation for N hemisphere 2010/2011
Dosage:

  • 6-35months: 0.25ml or 0.5ml (clinical data limited)
  • >36months & adults: 0.5ml
  • single dose vaccine; however in children who have not previously been vaccinated, second dose (booster) should be given after an interval of at least 4 weeks
  • intramuscular or deep subcutaneous injection

Seroprotection: achieved in 2-3 weeks, duration 6-12 months

Contains traces of:

  • residues of eggs, chicken protein eg. ovalbumin (propagated in fertilised hens’ eggs)
  • formaldehyde
  • gentamicin
  • polysorbate 80, cetyltrimethylammonium bromide

Use in pregnancy/lactation:

  • limited data do not indicate that adverse foetal and maternal outcomes were attributable to the vaccine
  • may be considered from second trimester
  • if medical condition increases risk of complication from influenza, vaccine may be warranted regardless of stage of pregnancy
  • may be used during lactation

Some common side effects:

  • headache, myalgia, arthralgia, fever, malaise, fatigue
  • local: redness, swelling, pain, ecchymosis, induration
  • rare: neuralgia, encelphalomyelitis, GBS

Posted August 25, 2010 by absinthemisia in Infectious Dis, influenza, vaccination

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Influenza vaccine: fluvax 2009/2010   2 comments

fluvax® 2009/2010 (CSL, Australia)
(from package insert, March 2009)

Vaccine type: purified, inactivated, split virion vaccine
Composition: conforms to requirements of the Vaccines and Related Biological Products Advisory Committee (VRBPAC) for northern hemisphere winter of 2009/2010

  • A/Brisbane/59/2007(IVR-148) or A/Brisbane/59/2007(H1N1)-like
  • A/Uruguay/716/2007(NYMC X-175C) or A/Brisbane/10/2007(H3N2)-like
  • B/Brisbane/60/2008 or B/Brisbane/60/2008-like

Dosage:

  • 6-35months: 0.25ml
  • >36months & adults: 0.5ml
  • single dose sufficient; however in children <9 years lacking prior antigenic exposure, and in those with impaired immunity, two doses are recommended separated by at least 4 weeks.
  • intramuscular or deep subcutaneous injection

Contraindicated in:

  • anaphylaxis to egg/chicken, neomycin, polymyxin B
  • acute febrile illness (fever >38.5c)

Use in pregnancy/lactation:

  • category B2 (no convincing evidence of risk to foetus)
  • may be offered to pregnant women who will be in 2nd or 3rd trimester during influenza season, including those in the 1st trimester at the time of vaccination

Some common side effects:

  • common: injection site inflammation, influenza-like illness
  • rare: neuralgia, paresthesia, convulsions, transient thrombocytopenia
  • very rare: encelphalomyelitis, GBS, vasculitis with renal involvement

drug interactions:

  • may impair P450 metabolism of warfarin, theophylline, phenytoin, phenobarbitone, cabamazepine

Posted December 1, 2009 by absinthemisia in influenza, vaccination

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What are the high-risk groups recommended for seasonal influenza vaccination?   1 comment

(from Ministry of Health circular, Singapore)
wef 1 Jan 2014: Medisave use for seasonal influenza vaccination will be allowed for the high-risk groups who are at increased risk of influenza-related complications.
(updated in MOH circular 42/2013 dated 6 Sep 2013)

  • persons ages 65 years and above, regardless of health condition
  • children 6 months to 59 months (<5 years)
  • chronic heart or lung diseases, including asthma
  • chronic metabolic diseases (eg. diabetes mellitus), renal, neurologic, hepatic, or haematologic disorders, or immunosuppression (including immunosuppression caused by medications or HIV)
  • children and teenagers (up to 18 years) receiving long-term acetylsalicylic acid and who may be at risk for developing Reye’s syndrome after influenza infection
  • women at all stages of pregnancy
  • persons receiving intermediate and long term care services

Posted November 17, 2009 by absinthemisia in influenza, vaccination

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Influenza vaccine: Influvac 2009/2010   Leave a comment

Influvac® 2009/2010 (Solvay, Netherlands)
(from package insert, April 2009)

Vaccine type: viral surface antigen (haemagglutinin & neuraminidase)
Composition: complies with WHO recommendation for N hemisphere 2009/2010
Dosage:

  • 6-35months: 0.25ml or 0.5ml (clinical data limited)
  • >36months & adults: 0.5ml
  • single dose vaccine; however in children who have not previously been vaccinated, 2nd dose (booster) should be given after an interval of at least 4 weeks
  • intramuscular or deep subcutaneous injection

Seroprotection: achieved in 2-3 weeks, duration 6-12 months

Contains traces of:

  • egg ovalbumin, chicken protein (propagated in fertilised hens’ eggs)
  • formaldehyde
  • gentamicin
  • polysorbate 80, cetyltrimethylammonium bromide

Use in pregnancy/lactation:

  • may be considered from 2nd trimester
  • if medical condition increases risk of complication from influenza, vaccine may be warranted regardless of stage of pregnancy
  • may be used during lactation

Some common side effects:

  • headache, myalgia, arthralgia, fever, malaise, fatigue
  • local: redness, swelling, pain, ecchymosis, induration
  • rare: neuralgia, encelphalomyelitis, GBS

Posted November 17, 2009 by absinthemisia in influenza, vaccination

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