Archive for the ‘Infectious Dis’ Category

Typhim Vi (Sanofi Pasteur)   Leave a comment

Typhim Vi™ (Sanofi Pasteur)
(typhoid vaccine)

Vaccine Type: polysaccharide vaccine
Composition: purified Vi capsular polysaccharides of Salmonella typhi (Ty2 strain) 25mcg/0.5ml

Dosage:

  • indicated for active immunisation over 5 years of age
  • 0.5ml per dose: im/sc one single dose
  • revaccination every 3 years if continued risk of exposure

Contraindicated in:

  • hypersensitivity to any component
  • not to be injected intravascularly
  • not indicated for <2y/o due to insufficient Ab response
  • delay vaccination if acute severe febrile illness

Pregnancy: insufficient data; pregnancy is not a reason not to administer vaccine in view of seriousness of disease and in case of high risk of exposure.
Lactation: caution is advised.

Adverse reactions:
usually moderate & of short duration
local injection site reactions (pain, edema, redness)
 

Ref:

  1. promotional material, Sanofi Pasteur

Posted December 13, 2011 by absinthemisia in vaccination

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Avaxim (Sanofi Pasteur)   Leave a comment

AVaxim™ 160 U (Sanofi Pasteur)
(Hepatitis A vaccine)

Vaccine Type: inactivated adsorbed vaccine
Composition: inactivated Hepatitis A virus, GBM strain, 160 units, cultured on MRC-5 human diploid cells, adsorbed on aluminium hydroxide (= 0.3mg of Al).

Dosage:

  • indicated for active immunisation from 16 years of age
  • 0.5ml per dose: im/sc one primary dose
  • booster for long-term protection: preferably 6-12 months, but may be administered up to 36 months after first dose
  • Avaxim may be used as booster dose if primary dose was given with another inactivated Hep A vaccine

Contraindicated in:

  • hypersensitivity to neomycin
  • not to be injected in the buttocks or intradermally
  • delay vaccination if acute severe febrile illness
  • response may be reduced in immunosuppressed
  • no studies done in subjects with liver disease

Pregnancy: avoid except in major contamination risk.
Lactation: consider benefit of breastfeeding for child, versus Avaxim for woman.

Adverse reactions:
usually mild, confined to first few days with spontaneous recovery

  • nausea, vomiting, diarrhoea, abdominal pain
  • headache, myalgia, arthralgia, asthenia
  • mild injection site pain, mild fever

Drug interactions:

  • immunoglobulins may be administered together at a different injection site
  • may be given with other inactivated vaccines at different site, including Typhim Vi and yellow fever vaccine

 

Ref:

  1. promotional material, Sanofi Pasteur

Posted December 13, 2011 by absinthemisia in viral hepatitis, Virology

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Influenza vaccine: Vaxigrip NH 2011/2012   Leave a comment

Vaxigrip NH 2011/2012 (sanofi-aventis)
(from promotional material)

Vaccine type: split virion, inactivated influenza vaccine
Composition:
<complies with WHO recommendation)

  • A/California/7/2009(H1N1)
  • A/Perth/16/2009(H3N2)
  • B/Brisbane/60/2008

Available in:

  • Vaxigrip Pediatric 0.25ml for 6-35 months of age
  • Vaxigrip 0.5ml for children & adults 36 months and older

Posted September 12, 2011 by absinthemisia in influenza, vaccination

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Influenza vaccine: influvac 2011/2012   Leave a comment

Influvac® 2011/2012 (Abbott)
(from promotional material)

Vaccine type: viral subunit vaccine (haemagglutinin & neuraminidase)
Composition:

  • A/California/7/2009(H1N1)-like virus
  • A/Perth/16/2009(H3N2)-like virus
  • B/Brisbane/60/2008-like virus

Posted August 12, 2011 by absinthemisia in influenza, vaccination

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Prevenar schedule (from Wyeth)   1 comment

based on material from Wyeth
for Prevenar use in Singapore for routine childhood immunisation, see here
for Prevenar use in Singapore for catch-up immunisation in children, see here

Age at first dose & number of doses:

  1. 2 – 6 months: 3 + 1
    • can give as early as 6 weeks old
    • interval between first 3 doses: 4-8 weeks
    • booster: at least 2 months after 3rd dose (approx. 12-15 months old)
  2. 7 – 11 months: 2 + 1
    • primary doses at least 4 weeks apart
    • booster dose after 1 year old & at least 2 months after 2nd dose
  3. 12 – 23 months: 1 + 1
    • at least 2 months apart
  4. 24 months through 9 years: 1 dose only

 
Ref:

  1. Product information and promotional material from Wyeth, WP-PREV-07/05-2-SG

Malaria Treatment   Leave a comment

  1. WHO Guidelines for malaria treatment 2010
  2. CDC Guidelines for malaria treatment: main article (2009)
  3. CDC Guidelines for malaria treatment: table summary (2009)
  4. CDC decision tree for malaria treatment

Posted September 14, 2010 by absinthemisia in malaria

Influenza vaccine: influvac 2010/2011   1 comment

Influvac® 2010/2011 (Solvay, Netherlands)
(from package insert, April 2010)

Vaccine type: viral surface antigen (inactivated) (haemagglutinin & neuraminidase)
Composition: complies with WHO recommendation for N hemisphere 2010/2011
Dosage:

  • 6-35months: 0.25ml or 0.5ml (clinical data limited)
  • >36months & adults: 0.5ml
  • single dose vaccine; however in children who have not previously been vaccinated, second dose (booster) should be given after an interval of at least 4 weeks
  • intramuscular or deep subcutaneous injection

Seroprotection: achieved in 2-3 weeks, duration 6-12 months

Contains traces of:

  • residues of eggs, chicken protein eg. ovalbumin (propagated in fertilised hens’ eggs)
  • formaldehyde
  • gentamicin
  • polysorbate 80, cetyltrimethylammonium bromide

Use in pregnancy/lactation:

  • limited data do not indicate that adverse foetal and maternal outcomes were attributable to the vaccine
  • may be considered from second trimester
  • if medical condition increases risk of complication from influenza, vaccine may be warranted regardless of stage of pregnancy
  • may be used during lactation

Some common side effects:

  • headache, myalgia, arthralgia, fever, malaise, fatigue
  • local: redness, swelling, pain, ecchymosis, induration
  • rare: neuralgia, encelphalomyelitis, GBS

Posted August 25, 2010 by absinthemisia in Infectious Dis, influenza, vaccination

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